Decree of the Ministry of Health No. 273 / 2000 Coll.
Decree of the Ministry of Health laying down the maximum permitted residues of veterinary medicinal products and bioactive substances used in animal production in food and food ingredients
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Effective from 01.09.2000
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273
DECLARATION
Ministry of Health
of 28 July 2000
laying down maximum permitted residues of veterinary medicinal products and bioactive substances used in animal production in foodstuffs and food ingredients
According to Section 19 (a) of Act No. 110 / 1997 Coll., on Food and Tobacco Products and on the amendment and addition of certain related laws:
This decree sets maximum permitted residues ("maximum residue levels') for veterinary medicinal products and biologically active substances used in animal production in food and food raw materials.
(1) For the purposes of this decree:
(a) veterinary medicinal products of all active substances and their mixtures or medicinal products under specific legislation, (1) except those administered to animals for the purpose of inducing active or passive immunity or diagnosis of immunity status;
(b) biologically active substances all additives which affect physiological functions and are administered to animals for purposes other than veterinary medicinal products,
(c) the maximum residue level for maximum residues of veterinary medicinal products and biologically active substances used in animal production which is permitted in or on the raw material of animal origin. The amount of residues is expressed in mg / kg of raw material. The conditions for the presence of residues in food and food ingredients, including the assessment method, shall be as set out in the Annex,
(d) the nature of the residues the presence of or on the food and food raw materials of the parent substance or their metabolism products;
(e) the parent substance of the parent active substance, unless otherwise specified in the Annex.
(2) When the maximum quantity of residues of veterinary medicinal products and bioactive substances used in animal production is exceeded, a food or food material shall not be considered to be inoperable.2)
(3) The purity and identity of veterinary medicinal products are laid down in specific legislation (3).
(1) In view of the nature of the maximum residue limit established, veterinary medicinal products are to be classified in the following groups:
(a) Group I, where maximum residue limits are established,
(b) Group II, where maximum residue levels are not established for human health in view of the identified safety status,
(c) Group III, where MRLs in the European Union are only provisional.
(2) Group IV lists medicinal products dangerous to human health which must not be used for food-producing animals.
This Decree shall take effect on 1 September 2000.
Minister:
Prof. MUDr. Fisher, CSc.
Annex to Decree No 273 / 2000 Coll.
Maximum residue levels
GROUP I
1. ANTI-INFECTION SUBSTANCES
Chemotherapies
1.1.1 Sulphonamides *:
All substances belonging to the sulfonamide group
Nature of residues: parent substance
| Druh živočichů | MLR1) (mg/kg) | Surovina |
|---|---|---|
| všechny druhy živočichů | 0,100 | maso, játra, ledviny, tuk |
| skot, ovce, koza | 0,100 | mléko |
* The final residue combination of all substances belonging to the sulfonamide group must not exceed 0,100 mg / kg.
1.1.2. Diamino pyrimidine derivatives:
Bakviloprim
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| skot | 0,300 | játra |
| 0,150 | ledviny | |
| 0,010 | tuk | |
| 0,030 | mléko | |
| prasata | 0,050 | játra, ledviny |
| 0,040 | kůže a tuk |
Trimethoprim
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| všechny druhy živočichů* s výjimkou lichokopytníků | 0,050 | maso, játra, ledviny, tuk, mléko |
| lichokopytníci | 0,100 | maso, játra, ledviny, tuk |
* Trimethoprim must not be used in animals whose eggs are produced for human consumption. Fat in pigs and poultry means fat including skin in natural form. Meat in fish means meat, including skin in natural form.
1.2 Antibiotics
1.2.1 Penicillins:
Amoxicillin
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| všechny druhy živočichů | 0,050 | maso, játra, ledviny, tuk |
| 0,004 | mléko |
Ampicillin
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| všechny druhy živočichů | 0,050 | maso, játra, ledviny, tuk |
| 0,004 | mléko |
Benzylpenicillin
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| všechny druhy živočichů | 0,050 | maso, játra, ledviny, tuk |
| 0,004 | mléko |
Dicloxacillin
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| všechny druhy živočichů | 0,300 | maso, játra, ledviny, tuk |
| 0,030 | mléko |
Phenoxymethylpenicillin
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| prasata | 0,025 | maso, játra, ledviny |
Cloxacillin
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| všechny druhy živočichů | 0,300 | maso, játra, ledviny, tuk |
| 0,030 | mléko |
Nafcillin *
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| skot | 0,300 | maso, játra, ledviny, tuk |
| 0,030 | mléko |
* Nafcillin is used only for intramammary application.
Oxacillin
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| všechny druhy živočichů | 0,300 | maso, játra, ledviny, tuk |
| 0,030 | mléko |
Penethamate
Nature of residues: benzylpenicillin
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| skot | 0,050 | maso, játra, ledviny, tuk |
| 0,004 | mléko | |
| prasata | 0,050 | maso, játra, ledviny, kůže a tuk |
1.2.2 Cephalosporins:
Cefacetril *
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| skot | 0,125 | mléko |
* Cefacetril is used only for intramammary application.
Cefalexine
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| skot | 0,200 | maso, játra, tuk |
| 1,000 | ledviny | |
| 0,100 | mléko |
Cephalonium
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| skot | 0,020 | mléko |
Cefapirine
Nature of residues: sum of cefapirin and desacetyl cefapirine
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| skot | 0,050 | maso, tuk |
| 0,100 | ledviny | |
| 0,060 | mléko |
Cefazoline
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| skot, ovce, koza | 0,050 | mléko |
Cefchinome
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| skot | 0,050 | maso, tuk |
| 0,100 | játra | |
| 0,200 | ledviny | |
| 0,020 | mléko | |
| prasata | 0,050 | maso, kůže a tuk |
| 0,100 | játra | |
| 0,200 | ledviny |
Cefoperazone
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| skot | 0,050 | mléko |
Ceftiofur
Nature of residues: sum of all residues containing the beta-lactam structure and determined as desfuroylceftiofur
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| skot | 1,000 | maso |
| 2,000 | játra, tuk | |
| 6,000 | ledviny | |
| 0,100 | mléko * | |
| prasata | 1,000 | maso |
| 2,000 | játra, kůže a tuk | |
| 6,000 | ledviny |
* It must not be used for intramammary application.
1.2.3 Quinolones:
Danofloxacin
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| skot, ovce, kozy | 0,200 | maso |
| 0,400 | játra, ledviny | |
| 0,100 | tuk | |
| 0,030 | mléko | |
| všechny druhy živočichů* s výjimkou skotu ovcí, koz a drůbeže | 0,100 | maso |
| 0,200 | játra, ledviny | |
| 0,050 | tuk | |
| drůbež ** | 0,200 | maso |
| 0,400 | játra, ledviny | |
| 0,100 | kůže a tuk |
* Meat in fish means meat including skin in natural form.
* * Danofloxacin must not be used in laying hens, their eggs are intended for human consumption.
Difloxacin
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| všechny druhy živočichů* s výjimkou skotu, ovcí, koz a drůbeže | 0,300 | maso |
| 0,100 | tuk | |
| 0,800 | játra | |
| 0,600 | ledviny | |
| skot**, ovce**, kozy** | 0,400 | maso |
| 1,400 | játra | |
| 0,800 | ledviny | |
| 0,100 | tuk | |
| drůbež *** | 0,300 | maso |
| 1,900 | játra | |
| 0,600 | ledviny | |
| 0,400 | kůže a tuk | |
| prasata | 0,800 | játra a ledviny |
| 0,400 | maso | |
| 0,100 | kůže a tuk |
* Meat in fish means meat including skin in natural form.
* * Difloxacin must not be used in animals whose milk is used for human consumption.
* * * Difloxacin must not be used in animals whose eggs are used for human consumption.
Enrofloxacin
Nature of residues: sum of enrofloxacin and ciprofloxacin
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| všechny druhy živočichů* s výjimkou skotu, ovcí, koz, prasat, králíků a drůbeže | 0,100 | maso, tuk |
| 0,200 | játra, ledviny | |
| skot, ovce, kozy | 0,100 | maso, tuk, mléko |
| 0,300 | játra | |
| 0,200 | ledviny | |
| králík | 0,100 | maso, tuk |
| 0,200 | játra | |
| 0,300 | ledviny | |
| prasata | 0,100 | maso, kůže a tuk |
| 0,200 | játra | |
| 0,300 | ledviny | |
| drůbež ** | 0,100 | maso, kůže a tuk |
| 0,200 | játra | |
| 0,300 | ledviny |
* Meat in fish means meat including skin in natural form.
* * Enrofloxacin must not be used in laying hens whose eggs are produced for human consumption.
Flumequine
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| všechny druhy živočichů, s výjimkou skotu, ovcí, koz, prasat, drůbeže a ryb | 0,200 | maso |
| 0,250 | tuk | |
| 0,500 | játra | |
| 1,000 | ledviny | |
| skot, ovce, kozy | 0,200 | maso |
| 0,500 | játra | |
| 1,500 | ledviny | |
| 0,300 | tuk | |
| 0,050 | mléko | |
| prasata | 0,200 | maso |
| 0,500 | játra | |
| 1,500 | ledviny | |
| 0,300 | kůže a tuk | |
| drůbež * | 0,400 | maso |
| 0,800 | játra | |
| 1,000 | ledviny | |
| 0,250 | kůže a tuk | |
| lososovité ryby | 0,600 | maso a kůže v přirozené podobě |
* Flumequine must not be used in animals whose eggs are produced for human consumption.
Oxolinic acid
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| prasata | 0,100 | maso |
| 0,050 | kůže a tuk | |
| 0,150 | játra, ledviny | |
| kur domácí * | 0,100 | maso |
| 0,050 | kůže a tuk | |
| 0,150 | játra, ledviny | |
| ryby | 0,100 | maso a kůže v přirozené podobě |
* Oxolinic acid must not be used in animals whose eggs are produced for human consumption.
Marbofloxacin
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| skot | 0,150 | maso, játra, ledviny |
| 0,050 | tuk | |
| 0,075 | mléko | |
| prasata | 0,150 | maso, játra, ledviny |
| 0,050 | kůže a tuk |
Sarafycin
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| kur domácí | 0,100 | játra |
| 0,010 | kůže a tuk | |
| lososovití | 0,030 | maso a kůže v přirozené podobě |
1.2.4. Macrolides:
Erythromycin
Nature of residues: erythromycin A
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| všechny druhy živočichů* | 0,200 | maso, tuk, játra, ledviny |
| 0,040 | mléko | |
| 0,150 | vejce |
* Meat in fish means meat including skin in natural form. Fat in pigs means fat including skin in natural form.
Spiramycin
Nature of residues (pigs): spiramycin 1
Nature of residues (other animals): sum of spiramycin and neospiramycin
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| skot | 0,200 | maso, mléko |
| 0,300 | játra, ledviny, tuk | |
| prasata | 0,250 | maso |
| 2,000 | játra | |
| 1,000 | ledviny | |
| kur domácí | 0,200 | maso |
| 0,400 | játra | |
| 0,300 | kůže a tuk |
Tilmicosin
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| všechny druhy živočichů* s výjimkou drůbeže | 0,050 | maso, tuk, mléko |
| 1,000 | játra, ledviny | |
| drůbež** | 0,075 | maso, kůže a tuk |
| 1,000 | játra | |
| 0,250 | ledviny |
* Meat in fish means meat including skin in natural form. Fat in pigs means fat including skin in natural form.
* * Tilmicosin must not be used in animals whose eggs are used for human consumption.
Tylosin
Nature of residues: tylosin A
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| všechny druhy živočichů* | 0,100 | maso, tuk, játra, ledviny |
| 0,050 | mléko | |
| 0,200 | vejce |
* Fat in pigs and poultry means fat including skin in natural form. Meat in fish means meat, including skin in natural form.
Acetyl isovaleryltylosin
Nature of residues: sum of acetylisovaleryltylosin and 3-O-acetyltylosin
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| prasata | 0,050 | maso, kůže a tuk, játra, ledviny |
1.2.5. Florfenicol and similar compounds:
Florfenicol
Nature of residues: sum of florfenicol and its metabolites measured as florfenicol-amine
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| všechny druhy živočichů s výjimkou skotu, ovcí, koz, prasat, drůbeže a ryb | 0,100 | maso |
| 0,200 | tuk | |
| 2,000 | játra | |
| 0,300 | ledviny | |
| skot*, ovce*, kozy* | 0,200 | maso |
| 3,000 | játra | |
| 0,300 | ledviny | |
| prasata | 0,300 | maso |
| 2,000 | játra | |
| 0,500 | ledviny, kůže a tuk | |
| drůbež ** | 0,100 | maso |
| 0,200 | kůže a tuk | |
| 2,500 | játra | |
| 0,750 | ledviny | |
| ryby | 1,000 | maso a kůže v přirozené podobě |
* Florfenicol must not be used in animals producing milk for human consumption.
* * Florfenicol must not be used in laying hens whose eggs are produced for human consumption.
Thiamphenicol
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| skot | 0,050 | maso, játra, ledviny, tuk, mléko |
| kur domácí * | 0,050 | maso, játra, ledviny, kůže a tuk |
* Thiamphenicol must not be used in laying hens whose eggs are produced for human consumption.
1.2.6 Tetracyclines:
Doxycycline
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| prasata, drůbež * | 0,100 | maso |
| 0,300 | játra, kůže a tuk | |
| 0,600 | ledviny | |
| skot ** | 0,100 | maso |
| 0,300 | játra | |
| 0,600 | ledviny |
* Doxycycline must not be used in laying hens whose eggs are produced for human consumption.
Doxycycline must not be used in dairy cows producing milk for human consumption.
Chlorotetracycline
Nature of residues: parent substance including 4 - epimer
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| všechny druhy živočichů | 0,100 | maso, mléko |
| 0,300 | játra | |
| 0,600 | ledviny | |
| 0,200 | vejce |
Oxytetracycline
Nature of residues: parent substance including 4 - epimer
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| všechny druhy živočichů | 0,100 | maso, mléko |
| 0,300 | játra | |
| 0,600 | ledviny | |
| 0,200 | vejce |
Tetracycline
Nature of residues: parent substance including 4 - epimer
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| všechny druhy živočichů | 0,100 | maso, mléko |
| 0,300 | játra | |
| 0,600 | ledviny | |
| 0,200 | vejce |
Ansamycin with naphthalene ring:
Rifaximin
Nature of residues: parent substance
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| skot | 0,060 | mléko |
1.2.8. Pleuromutilines:
Tiamulin
Nature of residues (chicken eggs): parent substance
Nature of residues (other raw materials): sum of metabolites that may be hydrolysed to 8-alpha-hydroxymutiline
| Druh živočichů | MLR (mg/kg) | Surovina |
|---|---|---|
| prasata, králík | 0,100 | maso |
| 0,500 | játra | |
| kur domácí | 0,100 | maso, kůže a tuk |
| 1,000 | játra | |
| 1,000 | vejce | |
| krůta | 0,100 | maso, kůže a tuk |
| 0,300 | játra |
Valnemulin
Nature of residues: parent substance
| Druh živočichů | MLR | Surovina |
|---|---|---|
| (mg/kg) | ||
| prasata | 0,050 | maso |
| 0,500 | játra | |
| 0,100 | ledviny |
1.2.9 Lincosamides:
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Regulation Information
| Citation | Decree of the Ministry of Health No. 273 / 2000 Coll., laying down the maximum permitted residues of veterinary medicinal products and bioactive substances used in animal production in food and food raw materials |
|---|---|
| Regulation Type | Order |
| Author | - |
| Collection | Code of Laws |
| Date of Promulgation | 18.08.2000 |
|---|---|
| Effective from | 01.09.2000 |
| Effective until | - |
| Status | Valid |
Legal Areas:
Administrative law
Agriculture
The regulation text is for informational purposes only.
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